Clinical management of thrombophilia-related placental vascular complications.
نویسنده
چکیده
Pregnancy is a hypercoagulable state with an increased thrombotic risk throughout gestation and the postpartum period. Women with thrombophilia may have a further increased risk of placental vascular complications, including pregnancy loss, preeclampsia, intrauterine growth restriction, and placental abruption. Preliminary data suggest that maternal antithrombotic prophylaxis may result in improved gestational outcome. Randomized trials are under way and hopefully will optimize maternal and neonatal outcome.
منابع مشابه
Thrombophilia, Anticoagulant Therapy, and Pregnancy Outcome in Women with Poor Obstetric History
Background: The role of anticoagulant medications in preventing placental mediated pregnancy complications in patients with and without thrombophilia has not been investigated well. One underlying cause is associated with adverse effects of anticoagulants in pregnancy including teratogenicity, complexities in dosing and management of anticoagulants during pregnancy and labor. We aimed to assess...
متن کاملThrombophilia and pregnancy complications.
Thrombophilic risk factors are common and can be found in 15% to 25% of Caucasian populations. Since pregnancy is an acquired hypercoagulable state, women harboring thrombophilia may present with clinical symptoms of vascular complications for the first time during gestation or at the postpartum period(1). Women with thrombophilia may have an increased risk of placental vascular complications, ...
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متن کاملDo placental lesions reflect thrombophilia state in women with adverse pregnancy outcome?
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متن کاملThrombophilia and Pregnancy Complications
There is a paucity of strong evidence associated with adverse pregnancy outcomes and thrombophilia in pregnancy. These problems include both early (recurrent miscarriage) and late placental vascular-mediated problems (fetal loss, pre-eclampsia, placental abruption and intra-uterine growth restriction). Due to poor quality case-control and cohort study designs, there is often an increase in the ...
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ورودعنوان ژورنال:
- Blood
دوره 103 11 شماره
صفحات -
تاریخ انتشار 2004